Invention Grant
- Patent Title: Conformationally stabilized HIV envelope immunogens
- Patent Title (中): 构象稳定的HIV包膜免疫原
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Application No.: US13585700Application Date: 2012-08-14
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Publication No.: US08715686B2Publication Date: 2014-05-06
- Inventor: Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
- Applicant: Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
- Applicant Address: US DC Washington US MA Boston
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,Dana-Faber Cancer Institute, Inc.
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,Dana-Faber Cancer Institute, Inc.
- Current Assignee Address: US DC Washington US MA Boston
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K39/21
- IPC: A61K39/21
Abstract:
Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.
Public/Granted literature
- US20120328641A1 CONFORMATIONALLY STABILIZED HIV ENVELOPE IMMUNOGENS Public/Granted day:2012-12-27
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