Invention Grant
US08715741B2 Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles
有权
使用智能聚合物纳米颗粒的水分散性口服，肠胃外和局部用于水溶性差的药物
- Patent Title: Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles
- Patent Title (中): 使用智能聚合物纳米颗粒的水分散性口服，肠胃外和局部用于水溶性差的药物
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Application No.: US13650273Application Date: 2012-10-12
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Publication No.: US08715741B2Publication Date: 2014-05-06
- Inventor: Anirban Maitra , Georg Feldmann , Savita Bisht
- Applicant: Anirban Maitra , Georg Feldmann , Savita Bisht
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/58
Abstract:
Polymeric nanoparticles with a hydrophobic core and a hydrophilic shell are formed from: 1) N-isopropylacrylamide (NIPAAM), at a molar ratio of about 50% to about 90%, and preferably 60% for specific delivery routes such as oral or parenteral; either water-soluble vinyl derivatives like vinylpryolidone (VP) or vinyl acetate (VA), or water insoluble vinyl derivatives like methyl methacrylate (MMA) or styrene (ST), at a molar ratio of about 10% to about 30%; and acrylic acid (AA), at a molar ration of about 10% to about 30%.
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