Invention Grant
US08715947B2 Inhibition of the interaction between 5T4 oncofoetal glycoproteins and CXC chemokine receptors as a method of identifying chemotaxis inhibitors
有权
作为鉴定趋化性抑制剂的方法，抑制5T4骨髓蛋白和CXC趋化因子受体之间的相互作用
- Patent Title: Inhibition of the interaction between 5T4 oncofoetal glycoproteins and CXC chemokine receptors as a method of identifying chemotaxis inhibitors
- Patent Title (中): 作为鉴定趋化性抑制剂的方法，抑制5T4骨髓蛋白和CXC趋化因子受体之间的相互作用
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Application No.: US13502893Application Date: 2010-10-20
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Publication No.: US08715947B2Publication Date: 2014-05-06
- Inventor: Peter L. Stern , Vaskar Saha
- Applicant: Peter L. Stern , Vaskar Saha
- Applicant Address: GB London
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB London
- Agency: Dann, Doreman, Herrell and Skillman
- Agent Patrick J. Hagan
- Priority: GB0918383.1 20091020
- International Application: PCT/GB2010/001940 WO 20101020
- International Announcement: WO2011/048369 WO 20110428
- Main IPC: G01N33/567
- IPC: G01N33/567 ; G01N33/574
Abstract:
Methods and agents are disclosed based on the finding that 5T4 interacts with CXCR4 in the cell membrane to form a complex, and that the 5T4 transmembrane region is involved in the promotion of CXCR4 membrane expression and chemotactic response.
Public/Granted literature
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