Invention Grant
US08715959B2 Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
有权
取代突变体受体及其在基于核受体的诱导型基因表达系统中的应用
- Patent Title: Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
- Patent Title (中): 取代突变体受体及其在基于核受体的诱导型基因表达系统中的应用
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Application No.: US10468193Application Date: 2002-02-20
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Publication No.: US08715959B2Publication Date: 2014-05-06
- Inventor: Subba Reddy Palli , Mohan Basavaraju Kumar , Dean Ervin Cress , Ted Tsutomu Fujimoto
- Applicant: Subba Reddy Palli , Mohan Basavaraju Kumar , Dean Ervin Cress , Ted Tsutomu Fujimoto
- Applicant Address: US VA Blacksburg
- Assignee: Intrexon Corporation
- Current Assignee: Intrexon Corporation
- Current Assignee Address: US VA Blacksburg
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/US02/05090 WO 20020220
- International Announcement: WO02/066612 WO 20020829
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12P21/04 ; C12N5/07 ; C12N5/071 ; C12N5/00 ; C12N15/00 ; C07H21/02 ; C07H21/04
Abstract:
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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