Invention Grant
- Patent Title: Expression of IL-12 family heterodimers
- Patent Title (中): IL-12家族异源二聚体的表达
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Application No.: US12992077Application Date: 2009-05-11
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Publication No.: US08715964B2Publication Date: 2014-05-06
- Inventor: Barbara K. Felber , George N. Pavlakis
- Applicant: Barbara K. Felber , George N. Pavlakis
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2009/043481 WO 20090511
- International Announcement: WO2009/140206 WO 20091119
- Main IPC: C12P21/04
- IPC: C12P21/04
Abstract:
The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g., in comparison to heterodimer expressed at an equimolar ratio.
Public/Granted literature
- US20110166210A1 IMPROVED EXPRESSION OF IL-12 FAMILY HETERODIMERS Public/Granted day:2011-07-07
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