Invention Grant
- Patent Title: Gene inactivated mutants with altered protein production
- Patent Title (中): 具有改变的蛋白质生产的基因失活的突变体
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Application No.: US12639956Application Date: 2009-12-16
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Publication No.: US08716004B2Publication Date: 2014-05-06
- Inventor: Huaming Wang
- Applicant: Huaming Wang
- Applicant Address: US CA Palo alto
- Assignee: Danisco US Inc.
- Current Assignee: Danisco US Inc.
- Current Assignee Address: US CA Palo alto
- Agency: Danisco US Inc.
- Main IPC: C12N1/00
- IPC: C12N1/00 ; C12N1/15 ; C07H21/02
Abstract:
A recombinant filamentous fungal cell (e.g. Aspergillus) having one or more inactivated chromosomal genes is provided. The chromosomal genes in some embodiments correspond to derA, derB, htmA, mnn9, mnn10, ochA, dpp4, dpp5, pepAa, pepAb, pepAc, pepAd, pepF and combinations thereof. The recombinant fungal cells may include further inactivated chromosomal genes which correspond to pepA, pepB, pepC and pepD. The recombinant filamentous fungal cells may include a heterologous nucleic acid encoding a protein of interest. Also provided are methods of producing a protein of interest in said recombinant filamentous fungal cell.
Public/Granted literature
- US20110070612A1 GENE INACTIVATED MUTANTS WITH ALTERED PROTEIN PRODUCTION Public/Granted day:2011-03-24
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