Invention Grant
- Patent Title: Micro RNAs for identification of exposure to lower aliphatic saturated aldehydes and the method of identification using thereof
- Patent Title (中): 用于鉴定暴露于低级脂族饱和醛的微RNA及其鉴定方法
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Application No.: US13689216Application Date: 2012-11-29
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Publication No.: US08716192B2Publication Date: 2014-05-06
- Inventor: Jae Chun Ryu , Mee Song , Ji-seong Yoon , Wooin Ryu , Hyo Sun Lee , Chan Young Shin
- Applicant: Korea Institute of Science and Technology
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Science and Technology
- Current Assignee: Korea Institute of Science and Technology
- Current Assignee Address: KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2012-0057452 20120530
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention relates to a biomarker for the identification of exposure to lower aliphatic saturated aldehydes by using micro RNA and a method for the identification of exposure to lower aliphatic saturated aldehydes using the same. In this invention, the micro RNA at least 1.5 fold up-regulated by exposure to lower aliphatic saturated aldehydes and the micro RNA up to 0.66 fold down-regulated by the same were selected. These two micro RNAs can be effectively used as the biomarker for the monitoring of lower aliphatic saturated aldehydes and for the risk assessment thereby and at the same time as a tool to investigate the mechanism of toxicity caused by such lower aliphatic saturated aldehydes.
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