Invention Grant
US08716243B2 Methods of effecting Wnt signaling through Dkk structural analysis
有权
通过Dkk结构分析实现Wnt信号传导的方法
- Patent Title: Methods of effecting Wnt signaling through Dkk structural analysis
- Patent Title (中): 通过Dkk结构分析实现Wnt信号传导的方法
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Application No.: US12454758Application Date: 2009-05-22
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Publication No.: US08716243B2Publication Date: 2014-05-06
- Inventor: Jie Zheng
- Applicant: Jie Zheng
- Applicant Address: US TN Memphis
- Assignee: St. Jude Childen's Research Hospital
- Current Assignee: St. Jude Childen's Research Hospital
- Current Assignee Address: US TN Memphis
- Agent Anna D. Digabriele Petti, Esq.
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/00 ; A61P19/08 ; A61P19/10
Abstract:
Compositions and methods related to Wnt signaling regulation by Dickkopf (Dkk) polypeptides and Wnt-related diseases are disclosed. For example, compounds that bind a Dkk or LRP polypeptide are disclosed. Compounds that disrupt binding of a Dkk polypeptide to an LRP polypeptide are also disclosed. Methods for using the described compounds and compositions are also disclosed.
Public/Granted literature
- US20090312253A1 Methods of effecting Wnt signaling through Dkk structural analysis Public/Granted day:2009-12-17
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