Invention Grant
- Patent Title: Preparation method of MLN4924 as an E1 activating inhibitor
- Patent Title (中): MLN4924作为E1激活抑制剂的制备方法
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Application No.: US13425212Application Date: 2012-03-20
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Publication No.: US08716304B2Publication Date: 2014-05-06
- Inventor: Lak Shin Jeong , Hyuk Woo Lee
- Applicant: Lak Shin Jeong , Hyuk Woo Lee
- Applicant Address: KR Seoul
- Assignee: EWHA University—Industry Collaboration Foundation
- Current Assignee: EWHA University—Industry Collaboration Foundation
- Current Assignee Address: KR Seoul
- Agency: Seed IP Law Group PLLC
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D497/00
Abstract:
The present invention relates to a method for preparation of MLN4924 as an E1 activating inhibitor, and more specifically, to a method for efficient and stereoselective preparation of MLN4924 by means of key steps involving stereoselective reduction of cyclopentenone with isopropylidene, regioselective cleavage of isopropylidene moiety, and synthesis of cyclic sulfate.
Public/Granted literature
- US20120330013A1 PREPARATION METHOD OF MLN4924 AS AN E1 ACTIVATING INHIBITOR Public/Granted day:2012-12-27
Information query
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