Invention Grant
- Patent Title: Inhibitors of diacylglycerol acyltransferase
- Patent Title (中): 二酰基甘油酰基转移酶抑制剂
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Application No.: US13129843Application Date: 2009-11-17
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Publication No.: US08716312B2Publication Date: 2014-05-06
- Inventor: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
- Applicant: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corporation
- Current Assignee: Merck Sharp & Dohme Corporation
- Current Assignee Address: US NJ Rahway
- Agent Kenrick L. Vidale; Janet E. Fair; Anna L. Cocuzzo
- International Application: PCT/US2009/064738 WO 20091117
- International Announcement: WO2010/059602 WO 20100527
- Main IPC: A61P3/00
- IPC: A61P3/00 ; A61P9/00 ; A61K31/445 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14
Abstract:
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below:
Public/Granted literature
- US20110224137A1 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE Public/Granted day:2011-09-15
Information query
