Invention Grant
- Patent Title: Positive allosteric modulators (PAM)
- Patent Title (中): 正变构调节剂(PAM)
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Application No.: US13741404Application Date: 2013-01-15
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Publication No.: US08716316B2Publication Date: 2014-05-06
- Inventor: Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Priority: EP09174136 20091027
- Main IPC: A61K31/4427
- IPC: A61K31/4427

Abstract:
The present invention relates to phenylethynyl compounds of formula I wherein R1, R2, X, L, R3, R4, R4′, cyc, and n are as defined in the specification and claims and to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They are useful for the treatment of schizophrenia or cognitive diseases.
Public/Granted literature
- US20130131056A1 POSITIVE ALLOSTERIC MODULATORS (PAM) Public/Granted day:2013-05-23
Information query
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