Invention Grant
- Patent Title: Class- and isoform-specific HDAC inhibitors and uses thereof
- Patent Title (中): 类别和异构体特异性HDAC抑制剂及其用途
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Application No.: US13389814Application Date: 2010-08-11
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Publication No.: US08716344B2Publication Date: 2014-05-06
- Inventor: Ralph Mazitschek , James Elliot Bradner
- Applicant: Ralph Mazitschek , James Elliot Bradner
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: President and Fellows of Harvard College,Dana-Farber Cancer Institute, Inc.
- Current Assignee: President and Fellows of Harvard College,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Agent C. Hunter Baker
- International Application: PCT/US2010/002220 WO 20100811
- International Announcement: WO2011/019393 WO 20110217
- Main IPC: A61K38/05
- IPC: A61K38/05 ; A61K31/495 ; C12Q1/48 ; A61K45/06 ; C07D239/42 ; C07D401/04
Abstract:
The present invention relates to compounds of the following formula wherein R3 is a fluorescent tag. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of the above formula in the presence of a test compound; and determining the activity of the HDAC protein.
Public/Granted literature
- US20120208889A1 CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF Public/Granted day:2012-08-16
Information query
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