Polysaccharide-grafted polyethylenimine as a gene carrier

Invention Grant

US08716399B2 Polysaccharide-grafted polyethylenimine as a gene carrier 有权

Title translation: 多糖接枝的聚乙烯亚胺作为基因载体

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Patent Title: Polysaccharide-grafted polyethylenimine as a gene carrier
Patent Title (中): 多糖接枝的聚乙烯亚胺作为基因载体
Application No.: US13299826

Application Date: 2011-11-18
Publication No.: US08716399B2

Publication Date: 2014-05-06
Inventor: Li-Fang Wang , Kuo-Hsun Sung , Yu-Lun Lo
Applicant: Li-Fang Wang , Kuo-Hsun Sung , Yu-Lun Lo
Applicant Address: TW Kaohsiung
Assignee: Kaohsiung Medical University
Current Assignee: Kaohsiung Medical University
Current Assignee Address: TW Kaohsiung
Agency: Volpe and Koenig, P.C.
Priority: TW100126252A 20110725
Main IPC: A61K47/48
IPC: A61K47/48

Polysaccharide-grafted polyethylenimine as a gene carrier

Abstract:

The present invention discloses a gene carrier and the preparation method thereof. Chondroitin sulfate (CS) is reacted with methacrylic anhydride (MA) to form chrondroitin sulfate-methacrylate (CSMA), which is further covalently bound with polyethylenimine (PEI) via the Michael addition to produce a CSMA-PEI gene carrier. The CSMA-PEI gene carrier can effectively reduce the cytotoxicity of PEI and enhance the transfection efficiency of PEI.

Abstract(Chinese):

本发明公开了一种基因载体及其制备方法。硫酸软骨素（CS）与甲基丙烯酸酐（MA）反应形成硫酸软骨素 - 甲基丙烯酸酯（CSMA），其通过迈克尔加成与聚乙烯亚胺（PEI）进一步共价结合以产生CSMA-PEI基因载体。 CSMA-PEI基因载体可以有效降低PEI的细胞毒性，提高PEI的转染效率。

Public/Granted literature

US20130030119A1 POLYSACCHARIDE-GRAFTED POLYETHYLENIMINE AS A GENE CARRIER Public/Granted day:2013-01-31

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