Invention Grant
US08716459B2 Isolated nucleic acid molecules encoding variant activin receptor polypeptides
有权
编码变体激活素受体多肽的分离的核酸分子
- Patent Title: Isolated nucleic acid molecules encoding variant activin receptor polypeptides
- Patent Title (中): 编码变体激活素受体多肽的分离的核酸分子
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Application No.: US13080515Application Date: 2011-04-05
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Publication No.: US08716459B2Publication Date: 2014-05-06
- Inventor: Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
- Applicant: Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Fenwick & West LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/06
Abstract:
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Public/Granted literature
- US20110183897A1 VARIANT ACTIVIN RECEPTOR POLYPEPTIDES Public/Granted day:2011-07-28
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