Invention Grant
US08716467B2 Methods and devices for nucleic acid synthesis 有权
用于核酸合成的方法和装置

  • Patent Title: Methods and devices for nucleic acid synthesis
  • Patent Title (中): 用于核酸合成的方法和装置
  • Application No.: US13038714
    Application Date: 2011-03-02
  • Publication No.: US08716467B2
    Publication Date: 2014-05-06
  • Inventor: Joseph Jacobson
  • Applicant: Joseph Jacobson
  • Applicant Address: US MA Cambridge
  • Assignee: Gen9, Inc.
  • Current Assignee: Gen9, Inc.
  • Current Assignee Address: US MA Cambridge
  • Agency: Greenberg Traurig, LLP
  • Agent Jennifer A. Camacho; Natalie Salem
  • Main IPC: C07H21/00
  • IPC: C07H21/00
Methods and devices for nucleic acid synthesis
Abstract:
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features. Each feature contains a plurality of oligonucleotides. Within each feature, each of the plurality of oligonucleotides includes an identical predetermined subunit sequence of X nucleosides and a degenerate sequence of Y nucleosides. A predetermined combination of a subset of the features can be used to produce a polynucleotide having a predetermined sequence of Z nucleosides.
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