Invention Grant
US08716482B2 Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
有权
取代的氨基哌啶作为二肽基肽酶-IV抑制剂用于治疗糖尿病
- Patent Title: Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
- Patent Title (中): 取代的氨基哌啶作为二肽基肽酶-IV抑制剂用于治疗糖尿病
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Application No.: US13390708Application Date: 2010-09-15
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Publication No.: US08716482B2Publication Date: 2014-05-06
- Inventor: Jason M. Cox , Tesfaye Biftu , Hong Dong Chu , Danqing Feng , Ann E. Weber
- Applicant: Jason M. Cox , Tesfaye Biftu , Hong Dong Chu , Danqing Feng , Ann E. Weber
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; Catherine D. Fitch
- International Application: PCT/US2010/048871 WO 20100915
- International Announcement: WO2011/037793 WO 20110331
- Main IPC: C07D211/32
- IPC: C07D211/32 ; A61K31/00
Abstract:
The present invention is directed to novel substituted aminopiperidines of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-ÏV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Public/Granted literature
- US20120149683A1 SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES Public/Granted day:2012-06-14
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