Invention Grant
US08716496B2 Sulfonated coumarins, their synthesis, fluorogenic substrates resulting from grafting of these coumarins on sugars, method for obtaining these substrates, and their applications
有权
磺化香豆素，它们的合成，由这些香豆素在糖上接枝而产生的荧光底物，获得这些底物的方法及其应用
- Patent Title: Sulfonated coumarins, their synthesis, fluorogenic substrates resulting from grafting of these coumarins on sugars, method for obtaining these substrates, and their applications
- Patent Title (中): 磺化香豆素，它们的合成，由这些香豆素在糖上接枝而产生的荧光底物，获得这些底物的方法及其应用
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Application No.: US13823294Application Date: 2011-09-16
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Publication No.: US08716496B2Publication Date: 2014-05-06
- Inventor: Antoine Drevelle , Sylvain Ladame , Majdi Najah , Estelle Mayot
- Applicant: Antoine Drevelle , Sylvain Ladame , Majdi Najah , Estelle Mayot
- Applicant Address: FR Nogent-sur-seine FR Strasbourg
- Assignee: Ets J. Soufflet,Universite de Strasbourg
- Current Assignee: Ets J. Soufflet,Universite de Strasbourg
- Current Assignee Address: FR Nogent-sur-seine FR Strasbourg
- Agency: Oliff PLC
- Priority: FR1003759 20100921
- International Application: PCT/FR2011/000504 WO 20110916
- International Announcement: WO2012/038614 WO 20120329
- Main IPC: C07D311/78
- IPC: C07D311/78 ; C12Q1/34 ; C07H15/24
Abstract:
Substituted sulfonated coumarins are expressed in the general formula (I), where: R1 is H, OH, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R2 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R1 and R2 being capable of together forming a ring, such as a substituted or unsubstituted aryl or furane, R3 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, where R4 is H, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or a substituted or unsubstituted aryl, and M is Na or K.
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