A regular expression pattern matching circuit based on a pipeline architecture is proposed, which is designed for integration to a data processing system, such as a computer platform, a firewall, or a network intrusion detention system (NIDS), for checking whether an input code sequence (such as a network data packet) is matched to specific patterns predefined by regular expressions. The proposed circuit architecture includes an incremental improvement on an old combination of a comparator circuit module and an NDFA (non-deterministic finite-state automata) circuit module, where the incremental improvement comprises a data signal delay circuit module installed to the comparator circuit module and an enable signal delay circuit module installed to the NDFA circuit module to thereby constitute a multi-sage pipeline architecture that allows a faster processing speed than the prior art.