The present invention relates to accurate positioning for vessel intervention procedures, particularly to a method for accurate positioning for vessel intervention procedures, a medical imaging system for accurate positioning for vessel intervention procedures and a catheterization laboratory system for accurate positioning for vessel intervention procedures. First, at least one X-ray image of a vessel region of interest is acquired (24) with injected contrast agent. Further, vessel information data is identified (26) within the at least one acquired image. Then, first calcification features of the vessel in the vessel region of interest in the at least one acquired image are detected (28). Further, vessel representation is generated (30) using the vessel information data and the detected calcification features. Further, at least one current fluoroscopic image of the vessel region of interest is acquired (32). Then, second calcification features of the vessel in the vessel region of interest in the at least one current fluoroscopy image are detected (34), wherein the second calcification features are according to the first calcification features. Further, the vessel representation is registered (36) with the fluoroscopy image, wherein the calcification features are used for the registration. Then, a composite image is generated (38) by combining the vessel representation with the at least one fluoroscopy image. Further, a composite image is displayed (40).