An automated method and computer program product are provided for reporting payments made to patients for their participation in a clinical study in a blinded manner to the sponsor of the clinical study. The clinical study has a plurality of investigative sites which perform activities in accordance with the protocol of the clinical study. Each patient has patient ID information and is assigned a subject ID that de-identifies the patient. Payment requests are received at a software application from the investigative sites associated with patient activity. The software application includes for each patient that is participating in the clinical study, the patient ID information, and the de-identified subject ID. The payment requests are associated with the patient ID information. The payment requests are processed at the software application, and payments that conform to predefined compensation guidelines for the clinical study are approved. The software application generates blinded payment reports for electronic delivery to the sponsor. The payment reports show at least the de-identified subject ID for each approved payment, the payment amounts for each approved payment, and a date associated with the payment.