The present general inventive concept relates to a syringe that, when connected to an endotracheal tube (ETT) cuff, automatically inflates the ETT cuff to a safe pressure in a single, full stroke of the syringe, and methods related thereto. The syringe includes a plunger, body, high pressure valve and low pressure valve. The syringe inflates an ETT cuff to a pressure high enough to seal the ETT cuff in a patient's trachea, but not high enough to cause damage. Then the pressure is reduced to a desired optimal pressure by releasing pressure through the low pressure valve.