Invention Grant
- Patent Title: T-cell receptor capable of recognising an antigen from cytomegalovirus
- Patent Title (中): 能识别巨细胞病毒抗原的T细胞受体
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Application No.: US13498564Application Date: 2010-09-29
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Publication No.: US08722048B2Publication Date: 2014-05-13
- Inventor: Hans Stauss , Shao-An Xue
- Applicant: Hans Stauss , Shao-An Xue
- Applicant Address: GB London
- Assignee: UCL Business PLC
- Current Assignee: UCL Business PLC
- Current Assignee Address: GB London
- Agency: Marshall, Gerstein & Borun LLP
- Priority: GB0917094.5 20090929
- International Application: PCT/GB2010/001820 WO 20100929
- International Announcement: WO2011/039507 WO 20110407
- Main IPC: A61K39/42
- IPC: A61K39/42 ; C07K14/725 ; C07K14/045
Abstract:
The present invention provides a T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID No. 1) when presented by a major histocompatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a CMV-specific T-cell. The present invention also provides the use of CMV-specific T-cell for cellular immunotherapy.
Public/Granted literature
- US20130045221A1 T-CELL RECEPTOR CAPABLE OF RECOGNISING AN ANTIGEN FROM CYTOMEGALOVIRUS Public/Granted day:2013-02-21
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