Invention Grant
- Patent Title: Dosage form with impeded abuse
- Patent Title (中): 剂量形式与滥用滥用
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Application No.: US12044586Application Date: 2008-03-07
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Publication No.: US08722086B2Publication Date: 2014-05-13
- Inventor: Elisabeth Arkenau-Marić , Johannes Bartholomaeus , Iris Ziegler , Marcel Haupts
- Applicant: Elisabeth Arkenau-Marić , Johannes Bartholomaeus , Iris Ziegler , Marcel Haupts
- Applicant Address: DE Aachen
- Assignee: Gruenenthal GmbH
- Current Assignee: Gruenenthal GmbH
- Current Assignee Address: DE Aachen
- Agency: Norris McLauglin & Marcus, P.A.
- Priority: DE102007011485 20070307
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K9/50 ; A61K9/16

Abstract:
A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm.
Public/Granted literature
- US20090004267A1 Dosage Form with Impeded Abuse Public/Granted day:2009-01-01
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