Invention Grant
- Patent Title: Solid dispersion and pharmaceutical composition of the same, and production processes thereof
- Patent Title (中): 固体分散体及其药物组合物及其制备方法
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Application No.: US12922029Application Date: 2009-03-10
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Publication No.: US08722094B2Publication Date: 2014-05-13
- Inventor: Kazushi Yoshida , Norimichi Okubo , Junichi Sakata , Hashime Kanazawa
- Applicant: Kazushi Yoshida , Norimichi Okubo , Junichi Sakata , Hashime Kanazawa
- Applicant Address: JP Tokyo
- Assignee: Aska Pharmaceutical Co., Ltd.
- Current Assignee: Aska Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2008-061126 20080311; JP2009-030376 20090212
- International Application: PCT/JP2009/054517 WO 20090310
- International Announcement: WO2009/113522 WO 20090917
- Main IPC: A61K9/14
- IPC: A61K9/14

Abstract:
A powdery porous carrier comprising a porous silicon-containing carrier is impregnated with a solution containing an organic solvent and an active ingredient hardly soluble in water, and the organic solvent is removed to give a solid dispersion having the active ingredient supported to the porous carrier without a treatment with a supercritical fluid. The porous silicon-containing carrier has a heating loss of not more than 4% by weight at a temperature of 950° C. for 2 hours (e.g., a spherical silicon-containing carrier such as a spherical porous silica). The porous silicon-containing carrier may be a spherical silica having a mean pore size of 10 to 40 nm and an oil absorption of 175 to 500 ml/100 g. A pharmaceutical composition (e.g., tablets, granules, or capsules) may be prepared from the solid dispersion and a pharmaceutically acceptable carrier. This invention provides a solid dispersion and a pharmaceutical composition (or a pharmaceutical preparation) which allows improvement in a solubility and a bioavailability of an active ingredient hardly soluble in water (e.g., a fibrate compound).
Public/Granted literature
- US20110020455A1 SOLID DISPERSION AND PHARMACEUTICAL COMPOSITION OF THE SAME, AND PRODUCTION PROCESSES THEREOF Public/Granted day:2011-01-27
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