Invention Grant
US08722324B2 Methods for the detection of HIV-1-specific antibodies employing GP41 polypeptides
有权
使用GP41多肽检测HIV-1特异性抗体的方法
- Patent Title: Methods for the detection of HIV-1-specific antibodies employing GP41 polypeptides
- Patent Title (中): 使用GP41多肽检测HIV-1特异性抗体的方法
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Application No.: US12977320Application Date: 2010-12-23
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Publication No.: US08722324B2Publication Date: 2014-05-13
- Inventor: Hana Golding , Surender Khurana
- Applicant: Hana Golding , Surender Khurana
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Baker & Hostetler LLP
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; A61K39/21
Abstract:
This invention relates to compositions and methods or the detection of human immunodeficiency virus-1 (HIV-1) infection by conducting an immunoassay comprising the steps of: (a) contacting a biological sample containing HIV-1 antibody with a peptide, having an epitope, of one or more of SEQ ID 49-56 to form a peptide-anti-HIV-1 antibody complex; (b) contacting the formed complex with an anti-HIV-1 antibody binding molecule to permit the anti-HIV-1 antibody binding molecule to bind to the anti-HIV-1 antibody of the formed peptide-anti-HIV-1 antibody complex and form an extended complex that is immobilized on a solid support; (c) removing unbound anti-HIV-1 antibody and anti-HIV-1 antibody binding molecule from the extended complex; and (d) determining the presence or concentration of the anti-HIV-1 antibody in the biological sample.
Public/Granted literature
- US20110201035A1 COMPOSITIONS AND METHODS FOR THE DETECTION OF HIV-1/HIV-2 INFECTION Public/Granted day:2011-08-18
Information query
