Invention Grant
US08722333B2 GSTP1 as teratogenic allele for autism and assays and methods based thereon
有权
GSTP1作为自闭症的致畸等位基因及其测定方法
- Patent Title: GSTP1 as teratogenic allele for autism and assays and methods based thereon
- Patent Title (中): GSTP1作为自闭症的致畸等位基因及其测定方法
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Application No.: US12449933Application Date: 2008-03-06
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Publication No.: US08722333B2Publication Date: 2014-05-13
- Inventor: William G. Johnson , Edward S. Stenroos
- Applicant: William G. Johnson , Edward S. Stenroos
- Applicant Address: US NJ New Brunswick
- Assignee: Rutgers, The State University of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Fox Rothschild LLP
- International Application: PCT/US2008/003052 WO 20080306
- International Announcement: WO2008/109147 WO 20080912
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34
Abstract:
The present invention provides novel markers and assays for autism based on the association of GSTP1 with prevalence for having a child or children with autism or autistic disease. The invention relates to the use and application of GSTP1 as a susceptibility marker and teratogenic allele for autism. In particular the genotype of GSTP1 at amino acids 105 and 114, corresponding to nucleotides 313 and 341 are determined. GSTP1 may be combined with other markers in methods and assays for monitoring, managing, diagnosis, prenatal diagnosis, and assessment of autism. In addition, the present invention discloses a novel method for identifying individuals who are genetically susceptible to have offspring with autism wherein the genotype of GSTP1, alone or in combination with other genetic markers or other indicators of oxidative stress, is determined.
Public/Granted literature
- US20100143318A1 GSTP1 AS TERATOGENIC ALLELE FOR AUTISM AND ASSAYS AND METHODS BASED THEREON Public/Granted day:2010-06-10
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