Invention Grant
US08722634B2 Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity
有权
使用从苦瓜属提取的化合物在制备用于预防和治疗糖尿病和肥胖症的药物中的用途
- Patent Title: Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity
- Patent Title (中): 使用从苦瓜属提取的化合物在制备用于预防和治疗糖尿病和肥胖症的药物中的用途
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Application No.: US12865843Application Date: 2009-01-14
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Publication No.: US08722634B2Publication Date: 2014-05-13
- Inventor: Yang Ye , Minjia Tan , Changqiang Ke , Tong Chen , Xiqiang Li , Edward Kraegen , Jiming Ye , David James , Gregory Cooney
- Applicant: Yang Ye , Minjia Tan , Changqiang Ke , Tong Chen , Xiqiang Li , Edward Kraegen , Jiming Ye , David James , Gregory Cooney
- Applicant Address: CN Shanghai AU Sydney
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,The Garvan Institute of Medical Research, Australia
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,The Garvan Institute of Medical Research, Australia
- Current Assignee Address: CN Shanghai AU Sydney
- Agency: Baker & Hostetler LLP
- Priority: CN200810033348 20080131
- International Application: PCT/CN2009/000050 WO 20090114
- International Announcement: WO2009/097735 WO 20090813
- Main IPC: A61K31/70
- IPC: A61K31/70
Abstract:
The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
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