Invention Grant
- Patent Title: Stabilized STAT3 decoy oligonucleotides and uses therefor
- Patent Title (中): 稳定的STAT3诱饵寡核苷酸及其用途
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Application No.: US13491343Application Date: 2012-06-07
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Publication No.: US08722640B2Publication Date: 2014-05-13
- Inventor: Jennifer R. Grandis , Daniel Johnson , Danith Ly
- Applicant: Jennifer R. Grandis , Daniel Johnson , Danith Ly
- Assignee: UNiversity of Pittsburgh - of the Commonwealth System of Higher Education
- Current Assignee: UNiversity of Pittsburgh - of the Commonwealth System of Higher Education
- Agency: Baker Botts L.L.P.
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/115 ; C12Q1/68
Abstract:
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
Public/Granted literature
- US20120288536A1 Stabilized Stat3 Decoy Oligonucleotides And Uses Therefor Public/Granted day:2012-11-15
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