Invention Grant
US08722851B2 Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A
有权
镇痛药具有极小的耐受性和依赖于μ阿片样物质受体激动剂，也与丝氨酸A结合
- Patent Title: Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A
- Patent Title (中): 镇痛药具有极小的耐受性和依赖于μ阿片样物质受体激动剂，也与丝氨酸A结合
-
Application No.: US12263257Application Date: 2008-10-31
-
Publication No.: US08722851B2Publication Date: 2014-05-13
- Inventor: Hoau-Yan Wang , Lindsay Burns Barbier , Jian Wang
- Applicant: Hoau-Yan Wang , Lindsay Burns Barbier , Jian Wang
- Applicant Address: US TX Austin
- Assignee: Pain Therapeutics, Inc.
- Current Assignee: Pain Therapeutics, Inc.
- Current Assignee Address: US TX Austin
- Agency: Husch Blackwell, LLP
- Main IPC: C07K14/00
- IPC: C07K14/00
Abstract:
A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W-[X1X2X3 . . . X43X44X45]nValAlaX48GlyLeu[X51X52X53 . . . X94X95X96]m-Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.
Public/Granted literature
Information query
