Invention Grant
US08722866B2 Isoform-selective inhibitors and activators of PDE3 cyclic nucleotide phosphodiesterases
有权
PDE3环核苷酸磷酸二酯酶的同种型选择性抑制剂和激活剂
- Patent Title: Isoform-selective inhibitors and activators of PDE3 cyclic nucleotide phosphodiesterases
- Patent Title (中): PDE3环核苷酸磷酸二酯酶的同种型选择性抑制剂和激活剂
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Application No.: US11654858Application Date: 2007-01-18
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Publication No.: US08722866B2Publication Date: 2014-05-13
- Inventor: Matthew A. Movsesian
- Applicant: Matthew A. Movsesian
- Applicant Address: US DC Washington
- Assignee: The United States of America, as Represented by the Department of Veterans Affairs
- Current Assignee: The United States of America, as Represented by the Department of Veterans Affairs
- Current Assignee Address: US DC Washington
- Agency: Gorman Law Offices
- Agent Robert Gorman
- Main IPC: C12N9/16
- IPC: C12N9/16 ; C12N9/18 ; C07H21/04 ; A61K31/495
Abstract:
The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments.
Public/Granted literature
- US20100267046A1 ISOFORM-SELECTIVE INHIBITOR AND ACTIVATORS OF PDE3 CYCLIC NUCLEOTIDE PHOSPHODIESTERASES Public/Granted day:2010-10-21
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