This disclosure describes techniques for region-of-interest (ROI) encoding. In accordance with the techniques described herein, an encoding device may determine a temporal spatial dependency value for a candidate reference video block for inter-coding a current block in a video frame. The encoding device may compare the temporal spatial dependency value to a threshold value and select a coding mode for the current block based on the comparison. A decoding device may receive data defining a ROI as well as the temporal spatial dependency value and decode a video block in the ROI based at least in part on the temporal spatial dependency value. In this manner, the techniques of this disclosure may allow a video content viewer the ability to choose a ROI to watch.