Configuration data and performance data can be collected from computing machines running a target program. Periods of stress for the computing machines can be identified using the performance data, and a set of the computing machines can be grouped under a stress profile using the performance data. One or more configuration points can be identified on the set of machines, and an effect of each of the configuration point(s) on performance of the set of machines can be inferred using the configuration data and the performance data. The inferred effect(s) of the configuration point(s) can be used to determine a baseline set of configuration settings.