A method for preventing Domain Name System (DNS) spoofing includes: performing uppercase/lowercase conversion for letters of a DNS question field in a DNS request packet according to a preset rule; sending the DNS request packet; receiving a DNS response packet; obtaining uppercase/lowercase distribution of the letters of the DNS question field in the DNS response packet; and forwarding the DNS response packet to a target DNS client if the uppercase/lowercase distribution of the letters of the DNS question field in the DNS response packet complies with the preset rule. Corresponding to the method, a device for preventing DNS spoofing is disclosed. The method and device reduce occupation of storage resources of the device.