A pair of scissors with an open second handle includes a first blade and a second blade pivotally connected by a pivot member. A first grip portion of the first handle surrounds the basal portion of a user's thumb, the thumb extends out of an inserting hole of the first blade in a lateral direction and presses against a first extension section, so that the user can hold the first grip portion with the thumb without bending too much at the wrist, thus enhancing stability of holding the scissors. The user's middle, ring and little fingers press against the grip section of the second handle, and the index finger rests against the second extension section. Besides, since the second grip portion is an open structure, the fingers of the user are supported but not restricted by the second grip portion, which improves stability and flexibility when using the scissors.