A droplet ejection device includes a droplet ejection head. The droplet ejection head includes droplet ejection nozzles, a common liquid chamber, an air vent nozzle, and a nozzle face. The ejection nozzles are arranged side by side in a vertical direction. Each ejection nozzle has a first channel to eject droplets. The vent nozzle has a second channel to vent air from the common chamber. The nozzle face is disposed in the vertical direction or a direction tilted downward relative to the vertical direction. The first channel is tilted downward so that a side proximal to the nozzle face is lower than another side proximal to the common chamber. The vent nozzle is disposed above a topmost one of the ejection nozzles. The second channel is tilted upward so that a side proximal to the nozzle face is higher than another side proximal to the common chamber.