A bone fixation system includes a bone plate having bi-directional combination holes extending therethrough, each hole being composed of a pair of domains and an interconnect which prevents the holes from overlapping. Each of the holes is configured and dimensioned to receive a set of full head bone screws adapted to be anchored into a bone or fragments thereof. The system also includes a pair of bone screws received in at least one of the combination holes, each bone screw having a shaft and a full head and being oriented in non-parallel directions. Various bone plate and screw embodiments are disclosed as is a method for fixating a bone fracture using the fixation system.