Invention Grant
- Patent Title: Methods of preventing or treating pain using anti-NGF antibodies
- Patent Title (中): 使用抗NGF抗体预防或治疗疼痛的方法
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Application No.: US13309153Application Date: 2011-12-01
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Publication No.: US08728473B2Publication Date: 2014-05-20
- Inventor: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T. L. Smith , Benjamin H. Dutzar
- Applicant: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T. L. Smith , Benjamin H. Dutzar
- Applicant Address: US NV Las Vegas
- Assignee: Alderbio Holdings LLC
- Current Assignee: Alderbio Holdings LLC
- Current Assignee Address: US NV Las Vegas
- Agency: LeClairRyan, a professional corporation
- Agent Robin L. Teskin
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28

Abstract:
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
Public/Granted literature
- US20120141485A1 METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES Public/Granted day:2012-06-07
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