Invention Grant
US08728477B2 Nucleotide and protein sequences of an antibody directed against an epitope common to human acidic and basic ferritins, monoclonal antibodies or antibody-like molecules comprising these sequences and uses thereof
有权
针对人类酸性和碱性铁蛋白原共有的表位的抗体的核苷酸和蛋白质序列，包含这些序列的单克隆抗体或抗体样分子及其用途
- Patent Title: Nucleotide and protein sequences of an antibody directed against an epitope common to human acidic and basic ferritins, monoclonal antibodies or antibody-like molecules comprising these sequences and uses thereof
- Patent Title (中): 针对人类酸性和碱性铁蛋白原共有的表位的抗体的核苷酸和蛋白质序列，包含这些序列的单克隆抗体或抗体样分子及其用途
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Application No.: US11902194Application Date: 2007-09-19
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Publication No.: US08728477B2Publication Date: 2014-05-20
- Inventor: Jean Kadouche , Emmanuelle Sabbah-Petrover , Olivier Chose
- Applicant: Jean Kadouche , Emmanuelle Sabbah-Petrover , Olivier Chose
- Applicant Address: IL Herzlia
- Assignee: Immune Pharmaceuticals Ltd.
- Current Assignee: Immune Pharmaceuticals Ltd.
- Current Assignee Address: IL Herzlia
- Agency: Zedek Latzer Baratz LLP
- Agent Mark S. Cohen; Pearl Cohen
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; A61K51/10 ; A61K39/00 ; C07K16/30
Abstract:
The present invention is directed to monoclonal, chimeric or humanized, antibodies or antibody-like molecules that recognize an epitope common to human acidic and basic isoferritins. The anti-ferritin antibodies or antibody-like molecules can be used in pharmaceutical compositions for immunotherapy or radioimmunotherapy to target various cancer cells in a mammal. A method for delivering anti-ferritin antibodies or antibody-like molecules to cancerous lymph cells, pancreatic cells, lymphatic endothelium cells, and liver cells is also disclosed, as well as methods for treating pancreatic cancer, hepatocellular carcinomas, Kaposi's sarcoma and Hodgkin's lymphoma.
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