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Invention Grant
US08728520B2 Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same 有权
用于封装的交联藻酸盐 - 聚亚烷基二醇聚合物涂料及其制备方法

Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same
Abstract:
A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material selected from the group consisting of cells, such as islets of Langerhans, pharmaceuticals, and biological agents. The coating can be formed by reacting an alginate-[polyalkylene glycol (PAG)-X1]n, and a multi-functional PAG-X2, to form covalent bonds, wherein n is an integer greater than 0, a first one of X1 and X2 is N3, and a second one of X1 and X2 is selected from the group consisting of: wherein R1=CH3, CH2CH3, CH(CH3)2, R2=N(CH3)2, OCH3, OH, CH3, H, F, Cl, Br or NO2, and R3=OCH3, CH3, H, F, Cl or NO2.
Abstract(Chinese):

公开了一种生物相容性胶囊，其包含通过共价稳定的包衣包封的生物材料及其制备方法。 生物材料可以是选自细胞的材料，例如朗格汉斯胰岛，药物和生物制剂。 涂层可以通过使藻酸盐 - [聚亚烷基二醇（PAG）-X1] n和多官能的PAG-X2反应形成共价键，其中n是大于0的整数，X1和 X2是N3，X1和X2中的第二个选自：其中R1 = CH3，CH2CH3，CH（CH3）2，R2 = N（CH3）2，OCH3，OH，CH3，H，F ，Cl，Br或NO 2，R 3 = OCH 3，CH 3，H，F，Cl或NO 2。

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