Invention Grant
- Patent Title: Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
- Patent Title (中): 监测和分析代谢活动概况的方法诊断和治疗用途
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Application No.: US13817543Application Date: 2012-04-04
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Publication No.: US08728758B2Publication Date: 2014-05-20
- Inventor: Reuven Tirosh , Fernando Patolsky , Hagit Peretz-Soroka
- Applicant: Reuven Tirosh , Fernando Patolsky , Hagit Peretz-Soroka
- Applicant Address: IL Tel-Aviv
- Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee Address: IL Tel-Aviv
- International Application: PCT/IL2012/050125 WO 20120404
- International Announcement: WO2012/137207 WO 20121011
- Main IPC: G01N33/50
- IPC: G01N33/50 ; G01N33/84 ; G06F19/12
Abstract:
A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.
Public/Granted literature
- US20130224789A1 METHODS OF MONITORING AND ANALYZING METABOLIC ACTIVITY PROFILES DIAGNOSTIC AND THERAPEUTIC USES OF SAME Public/Granted day:2013-08-29
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