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Invention Grant
US08728771B2 L-succinylaminoacylase and process for producing L-amino acid using it 有权
L-琥珀酰氨基酰化酶及其制备L-氨基酸的方法

L-succinylaminoacylase and process for producing L-amino acid using it
Abstract:
The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; or (d) a protein which consists of an amino acid sequence where one or several amino acid(s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity. This enzyme is able to produce a sterically bulky unnatural amino acid such as L-tert-leucine etc. which is useful as an intermediate for pharmaceuticals.
Abstract(Chinese):

本发明提供了一种L-琥珀酰基酰化酶，其由以下组成：（a）由由SEQ ID No：1所示的核酸序列组成的基因编码的蛋白质; （b）由SEQ ID No：2所示的氨基酸序列组成的蛋白质; （c）由严格条件下与SEQ ID No：1所示核酸序列互补且具有L-琥珀酰氨基酰化酶活性的核酸序列杂交的多核苷酸编码的蛋白质; 或（d）由氨基酸序列组成的蛋白质，其中一个或多个氨基酸被取代，缺失，插入和/或添加在由SEQ ID No：2所示的氨基酸序列组成的蛋白质中 并具有L-琥珀酰氨基酰化酶活性。 该酶能够产生空间庞大的非天然氨基酸如L-叔亮氨酸等，其可用作药物的中间体。

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