Invention Grant
US08728812B2 Compositions and methods for promoting the generation of PDX1+ pancreatic cells
有权
促进PDX1 +胰腺细胞产生的组合物和方法
- Patent Title: Compositions and methods for promoting the generation of PDX1+ pancreatic cells
- Patent Title (中): 促进PDX1 +胰腺细胞产生的组合物和方法
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Application No.: US12989284Application Date: 2009-04-22
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Publication No.: US08728812B2Publication Date: 2014-05-20
- Inventor: Shuibing Chen , Douglas A. Melton , Malgorzata Borowiak , Julia Lamenzo , Stuart L. Schreiber , Lee F. Peng , Lance Davidow , Kelvin Lam , Lee L. Rubin
- Applicant: Shuibing Chen , Douglas A. Melton , Malgorzata Borowiak , Julia Lamenzo , Stuart L. Schreiber , Lee F. Peng , Lance Davidow , Kelvin Lam , Lee L. Rubin
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: President and Fellows of Harvard College,The General Hospital Corporation
- Current Assignee: President and Fellows of Harvard College,The General Hospital Corporation
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Morse, Barnes-Brown & Pendleton, P.C.
- Agent Lisa M. Treannie, Esq.
- International Application: PCT/US2009/041381 WO 20090422
- International Announcement: WO2009/132083 WO 20091029
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/071 ; C12N5/02
Abstract:
Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
Public/Granted literature
- US20110070645A1 COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS Public/Granted day:2011-03-24
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