Invention Grant
- Patent Title: Methods for detecting lung cancer and monitoring treatment response
- Patent Title (中): 检测肺癌的方法和监测治疗反应
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Application No.: US12743042Application Date: 2008-11-24
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Publication No.: US08728823B2Publication Date: 2014-05-20
- Inventor: Stephen Lam , John Yee , Michael Kuzyk , Don Sin , Marianne Dorthy Sadar , Carl Martin Tammemagi
- Applicant: Stephen Lam , John Yee , Michael Kuzyk , Don Sin , Marianne Dorthy Sadar , Carl Martin Tammemagi
- Applicant Address: CA Vancouver, British Columbia
- Assignee: British Columbia Cancer Agency Branch
- Current Assignee: British Columbia Cancer Agency Branch
- Current Assignee Address: CA Vancouver, British Columbia
- Agency: Borden Ladner Gervais LLP
- Agent Gail C. Silver
- International Application: PCT/CA2008/002070 WO 20081124
- International Announcement: WO2009/065230 WO 20090528
- Main IPC: G01N33/00
- IPC: G01N33/00 ; G01N33/566

Abstract:
A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.
Public/Granted literature
- US20100248290A1 METHODS FOR DETECTING LUNG CANCER AND MONITORING TREATMENT RESPONSE Public/Granted day:2010-09-30
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