Invention Grant
- Patent Title: Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
- Patent Title (中): 基于增加结晶微粒表面对活性剂的亲和力的药物制剂的方法
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Application No.: US12830557Application Date: 2010-07-06
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Publication No.: US08729019B2Publication Date: 2014-05-20
- Inventor: Keith A. Oberg , Joseph Sulner
- Applicant: Keith A. Oberg , Joseph Sulner
- Applicant Address: US CA Valencia
- Assignee: Mannkind Corporation
- Current Assignee: Mannkind Corporation
- Current Assignee Address: US CA Valencia
- Agency: K&L Gates LLP
- Agent Louis C. Cullman; Hal Gibson
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/25 ; A61K38/27 ; A61K38/28 ; A61K38/29 ; A61K9/19
Abstract:
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.
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