Invention Grant
US08729038B2 Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles 有权
通过核酸加载的病毒样颗粒对基因表达的下调

  • Patent Title: Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles
  • Patent Title (中): 通过核酸加载的病毒样颗粒对基因表达的下调
  • Application No.: US12678150
    Application Date: 2008-09-12
  • Publication No.: US08729038B2
    Publication Date: 2014-05-20
  • Inventor: Jens GruberWolfgang Lüke
  • Applicant: Jens GruberGabriele Jansen
  • Agency: Saliwanchik, Lloyd & Eisenschenk
  • Priority: EP07018130 20070914
  • International Application: PCT/EP2008/007580 WO 20080912
  • International Announcement: WO2009/036933 WO 20090326
  • Main IPC: C12N15/11
  • IPC: C12N15/11 C07H21/04 A01N63/00
Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles
Abstract:
The present invention relates to compositions of virus-like particles for the introduction of RNA-interference (RNAi-) inducing molecules into eukaryotic cells and methods for the cell type-specific transduction of a plurality of eukaryotic cells with RNAi-inducing molecules. The present invention furthermore relates to methods for a diagnosis, prevention and/or treatment of diseases or disease states associated with an increased expression rate of at least one endogenous gene, and/or with the undesired expression of at least one endogenous gene and/or foreign nucleic acids, in particular viral nucleic acids.
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