Invention Grant
- Patent Title: Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles
- Patent Title (中): 通过核酸加载的病毒样颗粒对基因表达的下调
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Application No.: US12678150Application Date: 2008-09-12
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Publication No.: US08729038B2Publication Date: 2014-05-20
- Inventor: Jens Gruber , Wolfgang Lüke
- Applicant: Jens Gruber , Gabriele Jansen
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: EP07018130 20070914
- International Application: PCT/EP2008/007580 WO 20080912
- International Announcement: WO2009/036933 WO 20090326
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04 ; A01N63/00

Abstract:
The present invention relates to compositions of virus-like particles for the introduction of RNA-interference (RNAi-) inducing molecules into eukaryotic cells and methods for the cell type-specific transduction of a plurality of eukaryotic cells with RNAi-inducing molecules. The present invention furthermore relates to methods for a diagnosis, prevention and/or treatment of diseases or disease states associated with an increased expression rate of at least one endogenous gene, and/or with the undesired expression of at least one endogenous gene and/or foreign nucleic acids, in particular viral nucleic acids.
Public/Granted literature
- US20120046340A1 Down Regulation of the Gene Expression by Means of Nucleic Acid-Loaded Virus-Like Particles Public/Granted day:2012-02-23
Information query
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