Invention Grant
US08729101B2 1H-imidazole derivative having CB1, agonistic, CB1 partial agonistic or CB1 antagnistic activity
有权
具有CB1，激动性，CB1部分激动性或CB1止痛活性的1H-咪唑衍生物
- Patent Title: 1H-imidazole derivative having CB1, agonistic, CB1 partial agonistic or CB1 antagnistic activity
- Patent Title (中): 具有CB1，激动性，CB1部分激动性或CB1止痛活性的1H-咪唑衍生物
-
Application No.: US12203113Application Date: 2008-09-02
-
Publication No.: US08729101B2Publication Date: 2014-05-20
- Inventor: Cornelis G. Kruse , Josephus H. M. Lange , Arnoldus H. J. Herremans , Herman H. Van Stuivenberg
- Applicant: Cornelis G. Kruse , Josephus H. M. Lange , Arnoldus H. J. Herremans , Herman H. Van Stuivenberg
- Applicant Address: NL Weesp
- Assignee: Solvay Pharmaceuticals, B.V.
- Current Assignee: Solvay Pharmaceuticals, B.V.
- Current Assignee Address: NL Weesp
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner
- Priority: EP01203851 20010921
- Main IPC: A61K31/454
- IPC: A61K31/454 ; C07D401/02
Abstract:
The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I), wherein R and R1-R4 have the meanings given in the specification.
Public/Granted literature
- US20090181949A1 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY Public/Granted day:2009-07-16
Information query
IPC分类:
