Invention Grant
- Patent Title: Agomelatine hydrochloride hydrate and preparation thereof
- Patent Title (中): 盐酸阿维美素水合物及其制备
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Application No.: US13635063Application Date: 2011-03-17
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Publication No.: US08729131B2Publication Date: 2014-05-20
- Inventor: Hanbin Shan , Zhedong Yuan , Xueyan Zhu , Peng Zhang , Hongjuan Pan , Xiong Yu
- Applicant: Hanbin Shan , Zhedong Yuan , Xueyan Zhu , Peng Zhang , Hongjuan Pan , Xiong Yu
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratoires Servier
- Current Assignee: Les Laboratoires Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: CN201010126254 20100317
- International Application: PCT/CN2011/071910 WO 20110317
- International Announcement: WO2011/113362 WO 20110922
- Main IPC: A01N37/18
- IPC: A01N37/18 ; A61K31/16 ; C07C233/00 ; C07C235/00 ; C07C237/00 ; C07C239/00
Abstract:
The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.
Public/Granted literature
- US20130005820A1 AGOMELATINE HYDROCHLORIDE HYDRATE AND PREPARATION THEREOF Public/Granted day:2013-01-03
Information query
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