Invention Grant
- Patent Title: Agomelatine hydrobromide hydrate and preparation thereof
- Patent Title (中): 氢溴酸阿莫拉坦及其制备方法
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Application No.: US13635087Application Date: 2011-03-17
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Publication No.: US08729132B2Publication Date: 2014-05-20
- Inventor: Hanbin Shan , Zhedong Yuan , Xueyan Zhu , Peng Zhang , Hongjuan Pan , Xiong Yu
- Applicant: Hanbin Shan , Zhedong Yuan , Xueyan Zhu , Peng Zhang , Hongjuan Pan , Xiong Yu
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratoires Servier
- Current Assignee: Les Laboratoires Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: CN201010126263 20100317
- International Application: PCT/CN2011/071912 WO 20110317
- International Announcement: WO2011/113363 WO 20110922
- Main IPC: A01N37/18
- IPC: A01N37/18 ; A61K31/16 ; C07C233/00 ; C07C235/00 ; C07C237/00 ; C07C239/00
Abstract:
The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.
Public/Granted literature
- US20130012592A1 AGOMELATINE HYDROBROMIDE HYDRATE AND PREPARATION THEREOF Public/Granted day:2013-01-10
Information query
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