Invention Grant
US08729232B2 Aldehyde tags, uses thereof in site-specific protein modification
有权
醛标签，其在位点特异性蛋白质修饰中的用途
- Patent Title: Aldehyde tags, uses thereof in site-specific protein modification
- Patent Title (中): 醛标签，其在位点特异性蛋白质修饰中的用途
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Application No.: US12921131Application Date: 2009-03-20
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Publication No.: US08729232B2Publication Date: 2014-05-20
- Inventor: Jason S. Rush , Carolyn Bertozzi
- Applicant: Jason S. Rush , Carolyn Bertozzi
- Applicant Address: US CA Oakland
- Assignee: The Regents of The University of California
- Current Assignee: The Regents of The University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- International Application: PCT/US2009/037893 WO 20090320
- International Announcement: WO2009/120611 WO 20091001
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K16/00 ; C12N11/00
Abstract:
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
Public/Granted literature
- US20110117621A1 Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification Public/Granted day:2011-05-19
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