Invention Grant
- Patent Title: Antisense oligonucleotides for inhibition of microRNA-21
- Patent Title (中): 用于抑制microRNA-21的反义寡核苷酸
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Application No.: US13415685Application Date: 2012-03-08
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Publication No.: US08729250B2Publication Date: 2014-05-20
- Inventor: Joacim Elmén , Phil Kearney , Sakari Kauppinen
- Applicant: Joacim Elmén , Phil Kearney , Sakari Kauppinen
- Priority: DK200600478 20060403; DK200600615 20060501; DK200601401 20061030
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/11

Abstract:
The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.
Public/Granted literature
- US20120238618A1 Pharmaceutical Composition Comprising Anti-miRNA Antisense Oligonucleotides Public/Granted day:2012-09-20
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